Top 30 (+5) Supplements for Alzheimer’s Detoxification

In Alzheimer's-Proofing, General Information, Top '10s' by Matthew Bell

Introduction

In other posts (see, e.g., HERE and HERE), I’ve pointed out that some researchers suspect that certain varieties of dementia might be precipitated by exposure to toxins. “Exposure,” here, could be contact with things (from metals and mold to herbicides and pesticides) in the environment. Or it could possibly be due to drinking contaminated water or taking particular (and “hepatotoxic”[1] – see below) pharmaceuticals over a long period of time. Toxins may build up inside of your body over time. So, the question arises: Can “detoxication,” or the process of ridding your body of toxins, be a part of Alzheimer’s treatment or prevention?

In line with my “betting strategy” – that is, my emphasis on things to try to improve your odds of Alzheimer’s avoidance or Alzheimer’s survival – I’m going to say: Tentatively… yes.

The liver is of utmost importance, here.[2] As one herbalist put it: “The liver is your toxic-waste disposal plant.”[3] But there are many things that can go wrong with it. One manual[4] listed the four main reasons for liver strain or outright failure.

  • Exposure to poisons and toxins. Acute poisoning is occasionally a concern – particularly for a cognitively impaired individual. But the chief difficulty comes from chronic exposure. Even low quantities of a mildly toxic substance can have deleterious and detrimental, cumulative effects over long periods of time. To read additional information about the potential dangers of home-related toxins, see my article, HERE. For my database of household hazards, see HERE. (For plant poisons and allergy-triggering plants, see HERE and HERE.)
  • Inadequate diet/poor nutrition. Diets lacking in essential minerals and vitamins cannot support healthy liver function – or healthy brain function, for that matter. You’ll want to avoid or reduce “junk” foods – especially processed and sugar-rich foods. For more specifics on what (and what not) to eat, see my article on the Alzheimer’s “MIND Diet,” HERE.
  • Overindulgence in food/alcohol. Overeating and long-term alcohol use both heavily tax the liver. Readers interested in pursuing the alcohol angle, can click HERE.
  • Chronic drug use or abuse. This category includes such substances as caffeine as well as prescription drugs.

It is interesting to think about these categories in relation to the three hypothesized “subtypes” of Alzheimer’s Disease. (For more on this speculative taxonomy, see HERE.) These are:

  • Inflammatory Type I Alzheimer’s
  • Nutrient-Deficiency Type II Alzheimer’s
  • Brain-Toxicity Type III Alzheimer’s

Clearly, here, we’re focused on the hypothetical third type. If there really is a variety of Alzheimer’s that can be precipitated by exposure to environmental (or other) toxins, then it would be helpful to have some strategy in place for periodic liver (and other) detoxification.

One aspect of this can be addressed with various herbal and nutritional supplements. So, without any further ado, here is my list of some important supplements with reputations as detoxifiers.

The Top Thirty (30) Detoxification Supplements

1.     Apple Pectin (from Malus pumila)

To put is simply, “pectin” is a plant-based fiber. Usually found in fruits, pectin is often found in the baking aisle of your local supermarket, since (among other things) it’s used for thickening homemade jelly. (It’s also incorporated into certain cosmetic products, such as makeup “foundation” and hair conditioner, as well as pharmaceutical drugs, for example anti-diarrheal medications.)

Apples are one of the principal sources of pectin. And, apropos of our present topic, it turns out that Apple Pectin “[h]elps to detoxify heavy metals.”[5] It’s also available in capsule form.

2.     Arginine (L-Arginine)

Arginine is often employed for cardiovascular difficulties – for example, poor blood flow or circulation. But it also “[h]elps to detoxify ammonia, a by-product of protein digestion that can accumulate when the liver isn’t functioning correctly.”[6]

3.     Artichoke (Cynara scolymus)

Artichoke has been used medicinally by traditional healers. For one thing, it is reputed have anti-oxidant qualities. It’s also been employed similarly to Asparagus (see below) as a “hangover” cure. One reason for this is that is supposed to stimulate the liver’s production of bile.

But, along with Dandelion and Milk Thistle (and other herbs) Artichoke is also supposed to be a potent liver detoxifier. “Globe artichoke leaf has been used traditionally to increase bile flow and act as a protective agent against various toxins.”[7]

“In particular Globe Artichoke leaves have a well-established reputation for restoring liver health…”.[8] One herbalist effused: “You can – and should – literally inundate your diet with every sort of artichoke as much as possible. These products love your liver.”[9]

4.     Asparagus (Asparagus officinalis)

Asparagus is widely regarded as a potent alcohol “hangover” remedy. But, according to at least one peer-reviewed scientific journal, among its other “biological functions” is “the protection of liver cells” against various toxins.[10] In other words, it’s got detoxification qualities.

5.     Beet, Garden (Beta vulgaris vulgaris)

Believe it or not, Beets have been used as detoxifying agents for hundreds of years. “Betalains, particularly betanin, are powerful stimulators of the body’s own …detoxification enzymes that …help clear the system of environmental toxins known as xenobiotics – chemicals foreign to living organisms.”[11]

6.     Birch, American White (Betula pubescens)

This one lies a little off the beaten path. It’s sometimes recommended for joint problems. Herbalists Julie Bruton-Seal and Matthew Seal write that “[t]he fresh leaves or buds or birch offer a powerful …tea for general detoxing…”.[12] Birch is supposed to help get rid of toxins from the blood (similar to Burdock) and the kidneys/urinary tract (like Dandelion and Stinging Nettle).

7.     Broccoli (Brassica oleracea italica)

Wow: Broccoli! What to say?

It’s supposed to be a fantastic place to get Folic Acid (Vitamin B-9) – which is itself reputed to be an Alzheimer’s-proofing vitamin. (See “Top 10 Nutrient and Vitamin Supplements for Alzheimer’s.”)

Along with other green vegetables such as Cabbage (Brassica capitata), Brussels Sprouts (Brassica gemmifera), Kale (Brassica sabellica), Spinach (Spinacia oleracea), and so on, Broccoli is a fixture of the Alzheimer’s-friendly “MIND Diet.” (For much more detail on that – including specific recommendations – see HERE.)

But, wouldn’t you know it? Broccoli – at least in its “microgreen” form – is also reported to be a detoxifying agent. “Sulphoraphane, from broccoli-sprout extract, …stimulate[s] the body’s production of detoxification enzymes…”.[13] (For additional information on microgreens, see HERE and HERE.)

As a bonus, Broccoli’s sulphoraphane is also being investigated as a cancer-fighter. So, eat up! (Pinch your nose if you have to.)

8.     Burdock (Arctium lappa)

This is one of the top five detoxifiers, for sure. It may have a salubrious effect on the liver and other organs, but it’s really known a tonic for the blood.

“Burdock is a significant detoxing herb in both Western and Chinese medicinal traditions.”[14] “Burdock root, Dandelion root, Milk Thistle, and Red Clover all… aid in cleansing the blood-stream. …Burdock, echinacea, horsetail, and licorice[15] have detoxifying properties.”[16]

9.     Calendula (Calendula Officinalis)

Calendula is typically recommended for digestion-related conditions. For instance, it might be administered for various bowel and intestinal inflammations, gastro-esophageal reflux disease i.e., GERD), or even ulcers of one kind or another.

For our purposes, I note that some sources flatly report that “Calendula is a cleansing and detoxifying herb…”.[17]

10. Charcoal (Activated carbon)

This one is a bit different from some of the others on this list. First of all, it’s not an herb. Though, neither are Arginine, Citrulline, or Coenzyme-A (which see). Secondly, unlike Dandelion, Milk Thistle, and Yellow Dock, it doesn’t stimulate bile (that is, it’s not a choleretic). And charcoal doesn’t really get “circulated” throughout the body.

Instead, it basically passes straight through the digestive system. It basically works by physically encountering foreign or unwanted substances and absorbing them. Activated charcoal is ideal for this, since it has a huge and highly absorbent surface area.

Charcoal is sometimes administered in emergency rooms for certain types of acute poisonings or overdoses, such as from barbiturates, benzodiazepines, sedatives, and the like of that.

It doesn’t work on a lot of substances – for example, acids, cyanide, ethanol, or heavy metals. And it has to be ingested shortly after the poisonous substance was swallowed. It won’t work too long after exposure.

Additionally, if you take it alongside prescription medication – or even with your dinner – it may prevent your body from absorbing the drug or nutrients that you need.

Still, for all the caveats, I think that it’s good to have on hand… just in case.

11. Chicory (Cichorium intybus)

“Similar to dandelion, chicory also possesses liver cleansing and detoxifying properties.”[18] “Traditional foods that are noted for their beneficial effects on the liver include the bitter leaves of dandelion and chicory.”[19]

12. Chlorella (Chlorella vulgaris)

Alternative-medical guru Joseph Mercola states that “Chlorella …is one of the most powerful detoxification…” herbs.[20] He even opines that it specializes in ridding the body of heavy metals – including mercury. (See more on heavy-metal poisoning, see HERE and HERE.)

Another writer underscores this, writing: “Chlorella works to clear the body of toxins, heavy metals and poisons.”[21]

13. Chrysanthemum/Ju Hua Cha/Mum (Chrysanthemum morifolium)

This one comes from Asian medicine. Recently, the New York-based, Chinese-American newspaper Epoch Times reported that “chrysanthemum …helps to support the liver …[and] eliminate toxins… [Chrysanthemum tea] purifies the blood and improves blood flow. It detoxifies the liver and helps to improve vision and hearing.”[22]

A few other Chinese herbals should receive honorable mentions as detoxifying agents. Huang Lian (Rhizoma coptidis), Huang Qin (Radix Scutellariae), Ling Nut (Trapa natans), and Zhi Zi (Fructus Gardeniae) stick out in this regard. If you have a special affinity for traditional Asian medicine, then you might want these to your cabinet as well.

14. Cilantro/Coriander (Coriandrum sativum)

Like Basil (Ocimum basilicum), Cilantro is mostly employed as a spice. Also like basil, it is frequently used for digestive ailments, including cramps and gas. It also helps with bad breath – as does Parsley (Petroselinum crispum).

Recently, however, Cilantro has gained recognition as a “chelator.” Very roughly, chelation is a biochemical process whereby a substance – usually a metal – is converted into a form in which it can be excreted from the body. One danger of metals in the body is that they may be stored and build to toxic levels. So, the thinking goes, if we’ve been exposed to, or ingested, metals, then we may require chelation in order to rid ourselves of the offending material and guard against its lasting ill effects.

And… you probably guessed it. Cilantro is now regarded in some circles as facilitating this chelation process.

According to one source, Cilantro facilitated the excretion of aluminum, lead, and mercury.[23] As Balch notes: “Chlorella and cilantro are helpful for absorbing toxic metals.”[24]

15. Citrulline (Citrulline Malate; L-Citrulline)

Citrulline is used for a variety of ailments and conditions, many of which revolve around bodily weakness or debility, including chronic fatigue, diabetes, and erectile dysfunction. Because of these uses, Citrulline is also favored by athletes.

For our purposes, I note that “Citrulline …detoxifies ammonia, which damages living cells.”[25]

16. Clover, Red & White (Trifolium pratense & Trifolium repens)

“In traditional herbal terms, red clover is an ‘alterative.’ This means that it cleanses and detoxifies the system.”[26] White Clover is simply a sister species. Hint: You might have it growing in your yard. Don’t kill it. And, for goodness sakes, don’t expose yourself to pesticides. Why not harvest it; and eat it?

17. Coenzyme A (C21H36N7O16P3S)

This one is fairly complex. First of all, its actually generated in the body so long as one’s Vitamin-B-5 levels are optimal. “Taken as a supplement, coenzyme A …supports the manufacture of substances critical for the brain…”.[27] And, yep… it helps “remove toxins from the body.”[28]

18. Dandelion (Taraxacum officinale)

One of the several “weeds” on this list, it is rich in vitamins. “The young leaves boiled up into a tea or eaten fresh in salads are detoxifiers…”.[29] And, once again… the stuff grows like a weed. But, don’t treat it like one! It’s a detox powerhouse.

19. Dimethylglycine (DMG)

Recent scientific research suggests that “DMG can protect the liver… [and] aid in detoxification.”[30] As an added bonus, and like Folic Acid (see HERE) DMG reportedly also helps to decrease homocysteine in the body. Homocysteine is an amino acid that, in high amounts, supposedly increases a person’s risk for Alzheimer’s as well as cardiovascular conditions.

20. Garlic (Allium sativum)

Garlic is reputed to address (and prevent) heart disease and high blood pressure. It’s long been known as a powerful antibiotic. And many insist that it has anti-viral properties as well.

I have also written about it as a good addition to your Alzheimer’s regimen for other reasons. (See my “Top 25 Herbs for Treating (and Avoiding) Alzheimer’s”.) In addition to all this, writer Phyllis Balch calls garlic “[a] potent detoxifier.”[31]

21. Glutathione (C10H17N3O6S)

Glutathione is an antioxidant that actually produced by the liver. However, it is possible to supplement with it. You might wish to do so on the theory that it will give your body a possibly much-needed detoxification assist.

One source had this amazing testimony to share. “So powerful is the antioxidant protection offered by …glutathione that it was able to prevent amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) in …[a] laboratory model…”.[32]

Glutathione is sometimes administered intravenously to cancer patients. At the present time, there is not a huge amount of evidence about the effectiveness of taking supplements orally. But, as periodically reassert, I am merely trying to raise the probability that I will avoid Alzheimer’s Disease (and other forms of dementia). I’m not necessarily going to wait until Glutathione has gone through all the requisite clinical trials. If it’s safe – and from the information that I have laid eyes on – it appears to be, then I see its use on the level of a “bet.” I’m just stacking the odds in my favor as much as possible.

According to Balch, Glutathione “[a]ids in detoxifying” the body with a special emphasis on “reducing …the harmful effects …[of] drugs” of various kinds.[33]

Although I haven’t read this specifically in relation to Glutathione, you sometimes have to be careful supplementing with compounds that are produced by your own body. The reason, if I understand correctly, is that when your body produces a substance, it also monitors that substances levels with an aim toward regulating them and maintaining homeostasis. So, sometimes what can happen (and this may occur with hormones such as estrogen, testosterone, and even melatonin) is that when you supplement with a substance, your body dials down (or shuts off) its own production of that substance. I’m not entirely sure that this applies to Glutathione, but I submit that it’s something you might want to keep in the back of your mind. Perhaps it might be best to take it periodically.[34]

22. Green Tea (Camellia sinensis)

Green Tea is chock full of antioxidants. Specifically, it contains a kind of plant-derived “micronutrient” (i.e., a nutrient that humans require only in small, or “trace,” amounts) called a polyphenol.

“Tea polyphenols support the liver’s enzyme detoxification system, which eliminates free radicals and toxins from the body.”[35]

23. Lemon Water (Citrus × limon + H2O)

Lemon can also “[increase] oxygenation levels,”[36] which can have a neuroprotective effect on the brain. Furthermore, for those who are brave and inclined to try it, lemon water can also be used as an enema.[37]

24. Milk Thistle (Silybum marianum)

Also sometimes called St. Mary’s Thistle, “Milk thistle helps to detoxify the liver.”[38] In fact, it’s such a powerful liver-supporting agent that it can even be used for “the treatment and prevention of fibrosis and cirrhosis”.[39]

Milk Thistle should not be confused with Blessed Thistle (Cnicus benedictus), which also has some cleansing/detoxifying properties.[40]

25. Oregon Grape Root (Mahonia aquifolium)

Oregon Grape is “a general tonic” that has been used in traditional healing to address both kidney and liver issues.[41] “Oregon grape root detoxifies the body…”.[42]

26. Pau D’Arco (Handroanthus impetiginosus)

“Pau d’arco …has detoxifying properties.”[43] Among this is its capability as a laxative/purgative. It shares this property along with other herbs such as Aloe (Aloe barbadensis), Cascara Sagrada (Rhamnus purshiana),[44] Fumitory (for which, see the entry, above) and Senna (Cassia senna). Even Dandelion (also see above), Licorice (Glycyrrhiza glabra), and Yellow Dock (see below) have mild laxative qualities.

27. Spirulina (Arthrospira maxima & Arthrospira platensis)

Although it’s sometimes called “blue-green algae,” Spirulina appears to be a kind of “good bacterium” that falls under the general category of cyanobacteria. Word on the interwebs has it that this stuff can be extremely potent as a heavy-metal detoxifier.[45]

28. Stinging Nettle (Urtica dioica)

“Modern-day naturopaths …use depuratives such as urtica [sic] to improve detoxification and elimination, thus helping to reduce accumulated metabolic waste products in the body.”[46] (A “depurative” is a purifying or detoxifying herb.)

29. Turmeric (Curcuma longa)

Predominantly known as a potent anti-inflammatory herb,[47] Turmeric is revealing that it also many other surprising qualities. As I have written elsewhere (see HERE, HERE, and HERE), this inflammation-fighting activity may be quite useful if it turns out that (some forms of) Alzheimer’s are precipitated by brain inflammation.

In any case, it also has been suggested that Turmeric – specifically its curcuminoids – has various “detoxifying properties”.[48]

30. Yellow Dock (Rumex crispus)

Yellow Dock, also sometimes called Curly Dock, is regarded as an anti-inflammatory. It’s also prized for its purgative effects – particularly on the digestive system. However, of primary interest to us, here, is the fact that the cleansing ability of Yellow Dock “make[s] it an ideal liver-detox treatment…”.[49] This puts Yellow Dock in a class along with Dandelion, Milk Thistle, Red Clover and others on this list.

Five (5) Runners-up

1.     Boldo (Peumus boldus)

Boldo is supposedly useful for many digestive ailments. For example, it may be used to calm gastrointestinal upset and cramps. In this way, it is perhaps not unlike Guelder Rose (Viburnum opulus), also known as Crampbark. It may also kill bacteria and intestinal worms, like Wormwood (Artemisia absinthium).[50]

Unfortunately, also like these other plants, Boldo is sometimes said to be harmful in large amounts – or over a long time. So, take care.

Still, one writer comments that among its “rumored …benefits …is …detoxing the liver.”[51]

2.     Cysteine (L-Cysteine) & N-Acetylcysteine (NAC)

Researcher Phyllis Balch notes that Cysteine, and its sister, L-Cystine, “are important in detoxification.”[52] Ditto for their close cousin, NAC.[53]

Still, it’s a runner up on my list because of its uncertain relationship with homocysteine. As one scientific article puts it: “Alzheimer’s disease and cardiovascular diseases share a common risk factor, elevated blood levels of homocysteine, an amino acid which becomes elevated by inadequate dietary intakes of vitamins B2, B6, B9 (folate) and B12.”[54]

If you keep your Vitamin-B levels up, you should be fine. (For more information, see “Top Ten (10) Nutrient & Vitamin Supplements for Alzheimer’s.”) But… be mindful.

3.     Fumitory (Fumaria officinalis)

Fumitory is often used in homeopathic preparations. I underlined homeopathic in order to emphasize it. The basic difference between “homeopathy” and its complementary approach, allopathy, is this. In allopathic medicine, physicians treat symptoms by dispensing substances that produce opposite effects to those perceived by the physician. For example, if you have a fever, an allopath will prescribe a fever-reducer. Allopathic preparations tend to have quite a lot of active ingredient.

In homeopathic medicine, by contrast, a doctor will treat conditions by administering substances that tend to produce the same symptoms that are observed. However, in homeopathy, the amount of the substance is vanishingly tiny.

So, one might see the toxic Mercury (Hg) in certain homeopathic eardrops. And, as stated, fumitory, which contains the toxin fumarin, must be given carefully, under competent supervision, and only in minute quantities. Because of the danger, I can only conscionably list it as a “runner up.”

That said, it is still true that, along with Artichoke and Dandelion, Fumitory is sometimes listed as a potent “cholagogue,” that is, a substance that serves to “increase the flow and release of store bile from the gallbladder by stimulating gallbladder contraction.”[55] I advise you to consult a medical professional. Use Fumitory only with extreme caution.

4.     Ginseng, Chinese (Panax ginseng)

This is a bit of a change. To my knowledge, Ginseng isn’t poisonous or toxic in usual doses. And some sources list it as a detox agent.[56]

My main problem is that I simply couldn’t find a whole lot on Ginseng’s detoxifying activities. Ginseng is far better known as an “adaptagen” and a “revitalizer.”

Nevertheless, it’s arguably good for Alzheimer’s in general. “The German Commission E and the World Health Organization both approve Panax ginseng for use …in times of …declining capacity for work and concentration.”[57] For more information, see HERE, HERE, and HERE.

But, be advised: The name “Ginseng” is applied to at least nineteen (19) different plants! For a discussion, see my article, HERE.

5.     Methionine (L-Methionine)

Methionine assists the body in ridding itself of “harmful toxins.”[58] However, this has to be carefully tracked, since Methionine can convert to Homocysteine in the body, which (according to those in some research sectors) can increase a person’s chances of developing Alzheimer’s.[59]

Final Remarks

It is sometimes said that a farmer doesn’t grow a crop; he or she merely superintends while the plant grows itself. Likewise, some maintain that a doctor doesn’t heal the body. He or she just oversees while the body heals itself.

As I began by stating, the main job of detoxification is handled by your liver. Even so, your liver requires support. And it turns out “that a variety of natural compounds [activate] and [amplify] …the production …of protective and life-sustaining detoxification enzymes and antioxidants. Among these are curcumin, which comes from turmeric; green tea extract; resveratrol; sulphoraphane, derived from broccoli; and the omega-3 fat, DHA.” (For much more on Resveratrol, see HERE, HERE, HERE, and HERE. And for more on Omega-3 Fatty Acids, see HERE, HERE, HERE, HERE, and HERE.)

Many of these supplements – and others enumerated, above – have little to no listed side effects, can be easily obtained, and (therefore) can be added in to your diet with little difficulty.

However, supplements are not magical. An herbal capsule or tea cannot make up for poor overall nutrition and cannot undo (at least, not overnight) a lifetime of dietary (or other) damage.

The moral of this story is this: Structure your Alzheimer’s-support and detoxification plan around a good diet. Accept no substitute.

Eat your veggies! As mentioned previously, the Alzheimer’s-friendly “MIND Diet” revolves heavily around the consumption of greens and miscellaneous vegetables.

Many of these have detoxing properties. “The commonly prescribed ones are carrot, celery and beetroot (often with a little ginger root), green vegetable juices with mint for increased detoxification. Chlorella (algae) can be added to this …for a real detoxification boost.”

Additionally, you’ll want to consume good quality fruits. Berries are especially good, here. The Blueberry (Vaccinium corymbosum) and the Chilean Wineberry, or Maqui (Aristotelia chilensis) are standouts. I go into these HERE.

And you’ll definitely want to lay off (or entirely eliminate) the junk and processed food in your diet.

For a LOT more information on the dos and don’ts of dementia-prevention and dementia-treatment dieting, see my dedicated article: “The Alzheimer’s ‘MIND Diet’: What Should You Eat?

Notes:

[1] This word means toxic to the liver. The Greek word for “liver” was hepar. Cognates of this word – for instance, “hepatic” – routinely show up in herbal and medical dictionaries.

[2] Many of the herbs (and other substances) on my list focus on liver detoxification. But some also help to purify other bodily systems – for instance, the circulatory and excretory systems. For herbs that give an assist to our nervous systems, see HERE.

[3] Jack Ritchason, The Little Herb Encyclopedia, 3rd ed., Pleasant Grove, Utah: Woodland Health Books, 1995, p. 147.

[4] Phyllis Balch, Prescription for Nutritional Healing, 5th ed., New York: Avery; Penguin, 2010.

[5] Balch, Prescription for Nutritional Healing, p. 799.

[6] Balch, Prescription for Nutritional Healing, p. 337.

[7] Leah Hechtman, Clinical Naturopathic Medicine, Sydney, Australia: Elsevier Australia, 2012, p. 991, <https://books.google.com/books?id=Z9cMOSbgozIC&pg=PA991>.

[8] Patricia Loh, Detox At Home: How to Get Rid Of Harmful Toxins From Your Body, Malaysia: Oak Publ. 2016, p. 29.

[9] Lloyd Wright, Triumph Over Hepatitis C: An Alternative Medicine Solution, India: Unistar Books, 2002, p. 204.

[10] See, e.g., B. Kim, Z. Cui, S. Lee, S. Kim, H. Kang, Y. Lee, D. Park, “Effects of Asparagus officinalis Extracts on Liver Cell Toxicity and Ethanol Metabolism,” Journal of Food Science, vol. 74, no. 7, Sept. 2009, pp. H204-H208, <https://www.ncbi.nlm.nih.gov/pubmed/19895471>.

[11] Nathan Bryan and Carolyn Pierini, Beet The Odds, Austin, Tex.: Neogenis Laboratories, 2013, <https://books.google.com/books?id=pI9VDQAAQBAJ>.

[12] Julie Bruton-Seal & Matthew Seal, Backyard Medicine: Harvest and Make Your Own Herbal Remedies, New York: Castle Books; Quarto Publ., 2012, p. 14.

[13] Balch, Prescription for Nutritional Healing, op. cit., p. 258.

[14] Bruton-Seal & Seal, Backyard Medicine, op. cit., p. 22.

[15] For more on Licorice, see HERE. Licorice is related to Alfalfa (Medicago sativa), which also has some detoxification actions.

[16] Balch, Prescription for Nutritional Healing, op. cit., pp. 258 and 800.

[17] Disha Arora, Anita Rani, and Anupam Sharma, “A Review on Phytochemistry and Ethnopharmacological Aspects of Genus Calendula,” Pharmacognosy Reviews, vol. 7, no. 14, Jul.-Dec. 2013, pp. 179-187, <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841996/>.

[18] Steph Zabel, “Chicory (Cichorium intybus Asteraceae): A Root for the Season,” Cambridge Naturals, Dec. 1, 2015, <https://www.cambridgenaturals.com/blog/chicory>.

[19] Hechtman, Clinical Naturopathic Medicine, p. 253, <https://books.google.com/books?id=Z9cMOSbgozIC&pg=PA253>.

[20] “Chlorella: Use This Superfood to Help Remove Mercury From Your Tissues in Weeks,” Mercola [dot] com, Jan. 2, 2012, <https://articles.mercola.com/sites/articles/archive/2012/01/02/is-this-one-of-natures-most-powerful-detoxification-tools.aspx>.

[21] Beth Ley, Chlorella: The Ultimate Green Food: Nature’s Richest Source of Chlorophyll, DNA & RNA, Detroit Lakes, Minn.: BL Publ., 2003, p. 10.

[22] Margaret Trey, “Detox With Chrysanthemum Tea,” Epoch Times, Jun. 1, 2014; updated Oct. 25, 2018, <https://www.theepochtimes.com/detox-with-chrysanthemum-tea_706908.html>.

[23] Bruce Fife, Oil Pulling Therapy: Detoxifying and Healing the Body Through Oral Cleansing, Colorado Springs, Colo. Piccadilly Books, 2008, p. 144, <https://books.google.com/books?id=18bdNQAACAAJ&pg=pa144>.

[24] Balch, Prescription for Nutritional Healing, op. cit., p. 555.

[25] Balch, Prescription for Nutritional Healing, op. cit., p. 58. See also Lihua Zhu, Effects of Hepatic Triglyceride Accumulation on Hepatic Metabolism with Referance to Periparturient Cows, dissertation, Department of Dairy Science, Univ. of Wisconsin – Madison, Madison, Wis., 1999, pp. 7ff, <https://books.google.com/books?id=mDPZAAAAMAAJ>.

[26] “Historic Herbs: Red Clover for Hormone Balance and Detoxification,” Holland Landing Health Centre, Sept. 1, 2017, <https://hlhc.ca/news/historic-herbs-red-clover-hormone-balance-detoxification/>.

[27] Balch, Prescription for Nutritional Healing, op. cit., p. 79.

[28] Balch, Prescription for Nutritional Healing, op. cit., p. 308. See also David Jockers, “8 Proven Ways to Improve Your Detoxification System,” DrJockers [dot] com, n.d., <https://drjockers.com/improve-detoxification-system/>.

[29] Bruton-Seal & Seal, Backyard Medicine, op. cit., p. 52.

[30] Roger Kendall and John Lawson, “Recent Findings on N,N-Dimethylglycine (DMG): A Nutrient for the New Millennium,” Townsend Letter for Doctors and Patients, Port Townsend, Wash., MAY 2000; reproduced on VetriScience [dot] com, <https://www.vetriscience.com/white_papers/DMG_Townsend%20letter_2000.pdf>. This is seconded by Balch, who notes that DMG “detoxifies the body” and also “[e]hances immunity,” Prescription for Nutritional Healing, op. cit., p. 725.

[31] Balch, Prescription for Nutritional Healing, op. cit., p. 282.

[32] David Perlmutter and Alberto Villoldo, Power up Your Brain: The Neuroscience of Enlightenment, Carlsbad, Cal.: Hay House, 2011, p. 104, <https://books.google.com/books?id=pnn43II86MgC&pg=PA104>.

[33] In context, Balch is writing about substance-abuse situations. But, frankly, one of the reasons that Glutathione may be give to cancer patients is because chemotherapeutic drugs are among the most dangerous and damaging compounds our bodies can be exposed to (without immediate death). So, my guess is that Glutathione may be effective for detoxing from both prescription and nonprescription drugs – whether they are legal or illegal.

[34] This is sometimes referred to as “cycling.” You might take it once a week, for instance. Or you might take it every day for a week and then not again for two weeks. It’s probably wise to seek the advice of a medical professional or nutritionist. I am neither!

[35] Lester Mitscher and Victoria Toews, The Green Tea Book, New York: Avery; Penguin, 2008, <https://books.google.com/books?id=b3GOBLdPoxYC>.

[36] Hechtman, Clinical Naturopathic Medicine, p. 373, <https://books.google.com/books?id=Z9cMOSbgozIC&pg=PA373>.

[37] See Balch, Prescription for Nutritional Healing, op. cit., p. 339. Wheatgrass (Thinopyrum intermedium) and Coffee (e.g., Coffea arabica and Coffea canephora) also make for good detoxification enemas.

[38] Balch, Prescription for Nutritional Healing, op. cit., p. 390.

[39] Hechtman, Clinical Naturopathic Medicine, p. 267, <https://books.google.com/books?id=Z9cMOSbgozIC&pg=PA267>.

[40] See, e.g., Balch, Prescription for Nutritional Healing, op. cit., p. 131.

[41] Anthony J. Cichoke, Secrets of Native American Herbal Remedies: A Comprehensive Guide to the Native American Tradition of Using Herbs and the Mind/Body/Spirit Connection for Improving Health and Well-Being, New York: Avery; Penguin, 2001, <https://books.google.com/books?id=WQuy8Qgib9AC>.

[42] Balch, Prescription for Nutritional Healing, op. cit., p. 369.

[43] Balch, Prescription for Nutritional Healing, op. cit., p. 800.

[44] Cascara Sagrada is also sometimes listed as a cleansing/detoxifying agent. (Ibid., p. 131.) However, because of its laxative action, it should probably be used carefully.

[45] Elizabeth Walling, “Natural Heavy Metal Detox With Chlorella and Spirulina,” The Nourished Life (blog), Oct. 13, 2018, <https://livingthenourishedlife.com/natural-heavy-metal-detox-with/>.

[46] Hechtman, Clinical Naturopathic Medicine, p. 515, <https://books.google.com/books?id=Z9cMOSbgozIC&pg=PA515>.

[47] P. Ravindran, K. Babu, Kandaswamy Sivaraman, Turmeric: The Genus Curcuma, Boca Raton, Fla.: CRC Press; Taylor & Francis, 2007, p. 267, <https://books.google.com/books?id=P2ykHQi6RvMC&pg=pa267>.

[48] Ibid.

[49] Bruton-Seal & Seal, Backyard Medicine, op. cit., p. 48.

[50] Wormwood, like Black Walnut (Juglans nigra), has the ability to kill intestinal parasites. However, dosage is key. (For more on Black Walnut, see “Allergy-Triggering Plants.”)

[51] Malia Frey, “Boldo Tea: Benefits, Side Effects, and Preparations,” Very Well Fit, Feb. 21, 2019, <https://www.verywellfit.com/boldo-tea-benefits-and-side-effects-4163849>.

[52] Balch, Prescription for Nutritional Healing, op. cit., p. 58.

[53] See “Top 9 Benefits of NAC (N-Acetyl Cysteine),” HealthLine, n.d., <https://www.healthline.com/nutrition/nac-benefits>.

[54] Eddie Vos and Kilmer McCully, “Alzheimer’s Disease: Still a Perplexing Problem,” BMJ [The British Medical Journal], Jul 8, 2014, <https://doi.org/10.1136/bmj.g4433>.

[55] Hechtman, Clinical Naturopathic Medicine, p. 110, <https://books.google.com/books?id=Z9cMOSbgozIC&pg=PA110>.

[56] See, e.g., Steven Schechter, Fighting Radiation & Chemical Pollutants With Foods, Herbs & Vitamins: Documented Natural Remedies That Boost Your Immunity & Detoxify, Encinitas, Cal.: Vitalty, Ink [sic], 1991, p. 68, <https://books.google.com/books?id=SBMNAQAAMAAJ>.

[57] Hechtman, Clinical Naturopathic Medicine, p. 1121, <https://books.google.com/books?id=Z9cMOSbgozIC&pg=PA1121>.

[58] See, e.g., Balch, Prescription for Nutritional Healing, op. cit., p. 337; cf. p. 524.

[59] Hechtman, Clinical Naturopathic Medicine, p. 1092, <https://books.google.com/books?id=Z9cMOSbgozIC&pg=PA1092>.