12 Surprising Treatments for Alzheimer’s Dementia

In General Information, Top '10s' by Matthew Bell

12 Surprising Treatments for Alzheimer’s Dementia

Introduction

Straightforwardly, “treatments” are dietary or medical interventions that are tailored to address specific health deficits or pathologies. To state the obvious in plain English, when you think there’s a problem, you try to devise a solution. But Alzheimer’s is tricky because researchers are still in the position of having to guess about the root problem.

Elsewhere, I have catalogued “10 Possible Causes for Alzheimer’s (& How to Address Them).” At least in my own reading, these appeared to me to be among the most commonly mentioned hypothetical causes for the disease. They include the accumulation of beta-amyloid “plaques” and neurofibrillary “tangles,” a deficiency of the neurotransmitter acetylcholine, and an overabundance of the amino acid homocysteine, and other things.[1] (Click the above link for much more detail.)

In many ways, then, the “treatments” proposed in this article are geared toward the mitigation, relief, or reversal of one of more of the possible causes. Where relevant, I will note what cause is being addressed. But keep in mind that I have a fuller discussion of the causes and feel free to refer to it as needed or desired.

Also, understand that (most of) what follows in this article is probably best characterized with the heading “alternative” medicine. Readers who are interested in reding about more mainstream pharmaceutical recommendations can see my article HERE.

Caveats

Just a word or two of caution.

Firstly, I’m not a doctor. I’m not a dietician, either. Thus, the information presented here is given in good faith from my reflections on research that I have personally conducted. Usually, I will provide citations so that you can see and evaluate my source materials yourself. Basically, think of this article as giving you leads for your own follow-up investigations. I’m not trying to settle anything once and for all.

Secondly, and relatedly, many of the items on this list are highly controversial. Each of these has its vociferous proponents, and its equally vocal opponents. Again, I am not aiming to resolve these debates, here. In fact, by mentioning something, I’m not necessarily even endorsing it myself. My purpose is to make you aware of the lay of the land, options-wise.

Thirdly, in many ways, the treatments sort of “fall out” from a person’s views about the causes of Alzheimer’s. This means that certain readers might be more interested in some entries than in others simply because of what they believe about how Alzheimer’s begins or develops. But, at this time, the science is far from precise. So, there’s a sense in which the various options interconnect in complicated and sometimes interesting ways.

Twelve Surprising Treatments for Alzheimer’s

1.     Coconut Oil

In the introduction, I rehearsed a few of the best-known candidate causes for Alzheimer’s. However, there are others beyond the usual suspects. And here’s one of them.

Some people think that Alzheimer’s essentially results from energy deprivation in the brain. Those who take this line suggest that that cognitive impairment develops from a problem with the brain’s ability to use glucose.[2]

“In Alzheimer’s disease, brain cells have difficulty metabolizing glucose, the brain’s principal source of energy. …Ketone bypass the defect in glucose energy metabolism… Therefore, if enough ketones were available…, they could satisfy the brain’s energy needs. …”[3]

This bump in ketones occurs during fasting. But it can also come from ingesting a fatty acid called a “medium-chain triglyceride,” or MCTs. Wouldn’t you know it? Coconut oil is an important source.[4]

One author rhapsodizes that “…MCTs have produced better results in Alzheimer’s patients than any other treatment currently known to medical science. …The amount of MCTs in coconut oil is great enough to produce therapeutic blood levels of ketones.”[5]

2.     Sulphoraphane

Sulforaphane is an interesting one. Despite its somewhat forbidding name, it’s quite accessible, as it is a component of many green-leafy or cruciferous vegetables including some of the same offerings that were also rich in glutathione. Can you believe it?

It is a nutritional powerhouse that is credited with anti-inflammatory, antioxidant, and detoxification abilities. But it’s Alzheimer’s-fighting potential appears to go beyond these.

As discussed elsewhere, one feature of Alzheimer’s-afflicted brains is the appearance of various protein deposits – the aforementioned “plaques and tangles” – that interfere with neural activity and may also have a general neurotoxic[6] effect.

At least one scientific study suggested that sulforphane may actually “[inhibit] the generation and aggregation” of this debilitating gunk.[7]

3.     Glutathione

Another commonly cited potential cause for dementia is “oxidation” or “oxidative stress.” Some onlookers think that the accumulation of beta-amyloid plaques (and other features of Alzheimer’s) is a result of – or is at least bound up with – this oxidative damage.

Following this line of thought, “Studies …indicate that increasing the [body’s] antioxidative capacity through dietary or pharmacological intake of antioxidants can be beneficial in treatment of Alzheimer’s disease.”[8]

In this regard, glutathione has a reputation as a key antioxidant. In point of fact, glutathione is produced by our bodies. However, sadly, its “concentration” and production appear to decrease sharply with age. And increased “oxidative stress” may leave us more vulnerable to Alzheimer’s.[9]

What can be done?

Firstly, you need to think about your (or your loved one’s) diet. There’s really no getting away it. Computer scientists have a saying, abbreviated GIGO: Garbage in, garbage out. In their field, this has to do with a computer program’s sensitive dependence on what is entered in by the programmer. If the programmer types in “garbage,” the program may be lousy. But think about how this principle can relation to our health.

You really can’t expect your body to behave optimally if you fuel it with junk food. So, lay off the alcohol, processed foods, and sugar.

In place of these, you’ll need a found of fruits and vegetables. Some are excellent glutathione boosters. These include Arugula (Eruca vesicaria), Bok Choy (Brassica chinensis), Broccoli (Brassica italica), Brussels Sprouts (Brassica gemmifera), Cabbage (Brassica capitata), Cauliflower (Brassica botrytis), Chard (Beta vulgaris vulgaris), Garden Cress (Lepidium sativum), Kale (Brassica sabellica), Mustard (Brassica rapa), Rapeseed (Brassica napus), and Watercress (Nasturtium officinale).

Additionally, foods such as Artichokes (Cynara scolymus), various berries – Blueberry (Vaccinium corymbosum), Goji (Lycium chinense), Raspberry (Rubus idaeus), Strawberry (Fragaria × ananassa) – Cacao/Cocoa (Theobroma cacao), Catalase, Coenzyme Q10 (CoQ10), Hydroxytyrosol (C8H10O3), Olive (Olea europaea), Red Wine, and Spinach (Spinacia oleracea) all have propensities to fight oxidation.

Secondly, you need to ensure that you maintain a consistent and adequate exercise regimen and sleep schedule. (For some tips on the latter, see my articles HERE, HERE, and HERE.)

4.     Green Tea

While we’re on the subject of antioxidants, here’s another one that should probably be singled out for special attention: Green Tea (Camellia sinsensis).

As stated, Alzheimer’s is possibly – even if partially – a result of biochemical oxidation in the body.[10]

Once again, diet is fundamental to protection of your body’s neurons.[11] At the very least you’ll want to keep your levels of Vitamin-B Complex, Carotenoids (including the previously listed Astaxanthin, Beta Carotene, Lutein, and Lycopene), and Polyphenols within their optimal ranges. From a dietary perspective, this will involve eating generous helpings of quality fruits (especially berries), grains, and vegetables.[12] But it may also involve choice beverages such as …wait for it …green tea!

The bottom line is this. Research suggests that “Green Tea polyphenols protect neurons against P[arkinson’s] D[isease] and A[lzheimer’s] D[isease].”[13] One of the most remarkable of these polyphenols is Epi-Gallo-Catechin Gallate (EGCG).[14]

Other nutritional supplements can be quite helpful as well, for instance Milk Thistle (Silybum marianum), Selenium (Se), Turmeric (Curcuma longa), and Vitamin C (Ascorbic Acid) – all of which help boost your natural glutathione levels. You can even supplement with glutathione directly.

Finally, bear in mind that numerous other substances have antioxidant qualities. Some of the better known of these include Alpha Lipoic Acid (ALA), Astaxanthin (C40H52O4), Beta Carotene (C40H56), Beta Glucan (C18H32O16), Lutein (C40H56O2), Lycopene (C40H56), N-Acetyl-L-Cysteine (NAC), Resveratrol (C14H12O3), Super-Oxide Dismutase (SOD), and Vitamin E (Alpha-Tocopherol).

5.     Herbs

This category has consumed a lot of my attention on AlzheimersProof.com. For one thing, herbal supplements are easily acquired.

True, there may be considerable variation in quality and potency among various suppliers. (You can always try your hand at growing your own.) Still, I think these have potential for being of great assistance when it comes to staving off – or slowing down – Alzheimer’s.

Because I have gone into much greater detail elsewhere, I will really only list a few of my top choices, here. But I couldn’t neglect these entirely, as they are clearly major players in the realm of “alternative” dementia treatments.

So here are my Top Five Herbs for Alzheimer’s. For my entire list of Twenty-Five, see HERE.

·       Gingko (Gingko biloba)

If you’ve read continuously down this far, then you’ve probably noticed the recurring theme of antioxidants. And this is carried further with these herbal supplements.

There is little doubt but that ginkgo is a key player in the Alzheimer’s fight. In fact, according to one source, ginkgo is “[c]urrently the most widely prescribed treatment for A[lzheimer’s] D[isease] and other dementias in Germany… [It] is believed to work by stimulating nerve-cell activity in the brain while also improving blood flow and perhaps protecting against further cell damage as an antioxidant.”[15]

·       Magnolia (Schisandra chinensis)

Scientific research suggests that magnolia fruit has “a protective role in N[eurological] D[iseasess], including …neurodegenerative diseases” such as Alzheimer’s. Magnolia has several “neuroprotective mechanisms” including the aforementioned “antioxidation, suppression of apoptosis [i.e., cellular death – Ed.], anti-inflammation, regulation of neurotransmitters,” and other helpful things including “modulation of brain-derived neurotrophic factor (BDNF) related pathways” which, as far as I understand has to do with possible nerve growth or regrowth.[16]

·       Rosemary (Rosmarinus officinalis)

Another heavy lifter, rosemary is another potent antioxidant that may actually have the ability “to inhibit neuronal cell death”.[17] That is amazing news for Alzheimer’s sufferers. In fact, rosemary is so powerful, it may also be effective even as an essential oil in aromatherapy![18]

·       Saffron (Crocus sativus)

Prized as one of the world’s most exotic – and expensive – spices, saffron is also being shown to possess remarkable neuroprotective abilities. For example, it “has been identified as a memory-enhancing agent” and it has also reportedly “demonstrated effective antioxidant[,] …anti-inflammatory[,] and antiamyloidgenic abilities.”[19]

·       Turmeric (Curcuma longa)

Turmeric is an absolute supplement steamroller. It is an inflammation-fighting machine. Used “[i]n traditional South Asian medicine, turmeric (curcumin) …relieve[s] …Alzheimer’s disease due to its anti-inflammatory and antioxidant properties.”[20] At least one study suggested that Indians who eat curry regularly have better cognitive scores (when tested on the Mini Mental-State Examination, for more on which see HERE) and lower risk for dementia.[21]

For MUCH more on herbal supplements, see any (or all) of the following articles:

6.     Hormones

Let’s take these one at a time.

·       Estrogen

“Abundant evidence implicates sex steroid depletion in postmenopausal women as a risk factor for the development of A[lzheimer’s] D[isease].”[22] Another set of authors writes that “estrogen …plays a significant neuromodulatory and neuroprotective role.[23] The numerous estrogenic effects in the brain include the modulation of synaptogenesis, increased cerebral blood flow, mediation of important neurotransmitters and hormones, protection against apoptosis [i.e., cell death – Ed.], anti-inflammatory actions, and antioxidant properties. These multiple actions in the central nervous system support estrogen as a potential treatment for the cognitive decline associated with Alzheimer’s disease…”.[24]

·       Melatonin

Similarly to glutathione, “[d]aily melatonin production decreases with age, and in several pathologies, attaining its lowest values in Alzheimer’s dementia patients.”[25] Surely, this is a pity, especially since some investigators argue that melatonin has the ability to mitigate the sort of “neurodegeneration” that is typical of “…Alzheimer’s disease …, Parkinson’s disease …, and ischemia / reperfusion injury to the brain, i.e., stroke.”[26] But, arguably, it’s no coincidence.[27]

·       Progesterone

A close cousin to estrogen in this regard, “…progesterone  …facilitates some forms of learning and memory” and has been suspected to be a factor in a particular mouse-centered “model of Alzheimer’s disease.”[28] The reduction of both females sex hormones – estrogen and progesterone – “appears to be a significant risk factor for the development of A[lzheimer’s] D[isease] in women.”[29] There is some hope that hormone-replacement therapies can help reduce this risk.[30]

·       Testosterone

There are a couple of things going on, here. Most obviously, since testosterone levels decrease as men age whereas Alzheimer’s risk increases, “some researchers [have] proposed a relationship between the development of A[lzheimer’s] D[isease] and reductions of T[estosterone].”[31]

But, relatedly, in men who possess the Alzheimer’s predisposing Apolipoprotein-E4 gene, there is a link between “reductions in testosterone” and “the development of the amyloid beta …and tau …proteins” that gunk of the brain by way of forming plaques and tangles.

Because of these observations, a few writers even make the bold and provocative (but probably unproven) claim that “…Alzheimer’s can be cured in its early stages and halted in in its later stages …primarily using testosterone.”[32] It’s something to keep your eye on.

7.     Lithium

First of all, lithium exhibits neuroprotective properties and may guard against neuronal “apoptosis,” that is, cell death.[33] Second, and relatedly, it may help to break up – or discourage the formation of – the plaques and tangles that are among the main indications of the presence of Alzheimer’s.[34]

Lithium can be obtained from various foods, including coffee, dairy (e.g., cheese and milk), eggs, grains (rice, wheat), kelp, legumes (beans, chickpeas, lentils, peas, soybeans), mushrooms (like the Groundwart, Thelephora vialis), seafoods (like lobsters, oysters, shrimp, and scallops), nuts (like pistachios), and miscellaneous other vegetables (e.g., cucumbers and nightshade plants such as peppers, potatoes, and tomatoes).

But lithium can also be added to your diet by way of supplementation. Like calcium, magnesium, and zinc, lithium comes in a variety of forms, such as aspartate,[35] carbonate, chloride, citrate, and orotate. Of these, at least one source’s recommendation was states as follows. “Studies that have compared lithium orotate to lithium carbonate have found that lower doses or lithium orotate can achieve therapeutic brain lithium concentrations while avoiding toxicity.”[36]

8.     Marijuana

Wow. Here’s a hot topic right now. I realize that there is something of a sharp divide on this one. I don’t really want to wade deeply into a political debate. So, let me try to keep things fairly neutral – if possible.

One author observes: “Research suggests that cannabinoids (which are potent antioxidants) might be especially useful in minimizing inflammatory responses in the brain itself, symptoms of which are believed to be key to many serious neurodegenerative diseases ranging from Alzheimer’s dementia, to Parkinson’s disease, to other related motor disorders…”.[37]

Another, apparently amateur, researcher (of questionable accuracy) nevertheless echoes this, writing: “The cannabinoids of Cannabis sativa are neuro-protective and anti-inflammatory.”[38]

9.     Nicotine

“Drugs acting at nicotinic receptors including nicotine itself have been tested as treatments for cognitive impairments, including those seen in Alzheimer’s disease, schizophrenia, and attention deficit hyperactivity disorder (ADHD).”[39]

One source relates: “In Alzheimer’s disease patients, attentional performance has been found to be significantly improved with nicotine…”.[40] This “significant” improvement was demonstrated, for instance, through various activities evaluated on an attention-focused assessment called the Conners’ Continuous Performance Test (CPT, 3rd Ed.). Nicotine administered through a patch for nearly a month seemed to elicit “a true increase in response accuracy”.

Another flatly states: “Nicotine treatment significantly improves cognitive function in people with mild-to-moderate Alzheimer’s disease.”[41]

10. Omega-3 Fatty Acids

This should be another dietary addition. Omega 3s are anti-inflammatory. “In addition, clinical studies have reported …the efficacy of omega-3 fatty acid in patients with attention-deficit hyperactivity disorder …, neurodegenerative disease such as Alzheimer’s disease …, and psychiatric disorders such as depression…”.[42]

Some randomized, controlled trials suggest that “omega-e …supplementation, particularly DHA, reverse age-related cognitive decline in otherwise healthy individuals… but these is less evidence to suggest such an effect in individuals with mild cognitive impairment and Alzheimer’s disease.”[43]

Still, “[e]pidemiological studies have shown that omega-3 fatty acid consumption reduces the risk of dementia… especially Alzheimer’s disease.”[44]

But, you need to watch the sort of fats that you eat. Overindulgence in saturated fats leads “to an increased risk of mixed dementia.”[45]

Some of the best sources include Cod-Liver Oil, Fish Oil, Flaxseed Oil, and Krill Oil.[46]

11. Red Wine/Resveratrol

Resveratrol, one of the active ingredients in red wine, is sometimes touted as an “anti-aging” drug.[47]

One of the telltale features of Alzheimer’s is the presence in the brain of the hardened plaques and tangles – mentioned elsewhere in this article and on my website – that interfere with neuronal activity and seem to “kill off” portions of the brain. Some researchers maintain that “[r]esveratrol is useful is stimulating the break-down [sic] of beta-amyloid peptides… In a study involving laboratory animals …who were given resveratrol from 45 days, there was a 45% reduction in plaques in the medial cortex, 89% in the stratum, and 90% in the hypothalamus.”[48]

Of course, with alcohol, one must remember the word moderation. (Some research seems to indicate that cognitive impairments can be precipitated by overindulgence. See HERE.)

Another thing to keep in mind is that not all wines are equal in their potential health benefits. Red wines tend to be healthier than white, and dry wines tend to edge out their sweeter counterparts.

Some of the red wines that often recommended include: Cabernet Sauvignon, Madiran, Malbec, Merlot, Petite Sirah, Pinot Noir, Rosé, Shiraz/Syrah, St. Laurent, and Zinfandel. Of these, three that stand out for resveratrol content seem to be Malbec, Pinot Noir, and St. Laurent.

  • For more on wines and Alzheimer’s, see HERE.

12. Vitamins

As an untutored layman, one of the most surprising things to me in my reading about Alzheimer’s is its association with various deficiencies. I go into this more deeply in other places. (See HERE.) So I will limit myself to two examples, presently.

·       Vitamin B

“[C]ertain of the B vitamins …, when lacking or deficient in our diets, can …easily produce a loss of vital memory. …[T]here of them …[are]: vitamin B-1, or thiamin; B-3, niacin or nicotinic acid;[49] and B-12.”[50]

The esteemed Mayo Clinic relates: “Some studies suggest low vitamin B-12 levels may be associated with an increased risk of dementia.”[51]

·       Vitamin D

Vitamin D is another such vitamin. Once again, I will appeal to the Mayo Clinic, which states that some “[r]esearch suggests that people with very low levels of vitamin D in their blood …are more likely to develop Alzheimer’s disease…”.[52]

First of all, it has anti-inflammatory properties. And the devil of it is, is that we actually produce it ourselves if we get enough sunlight exposure.

Joseph Mercola relates this to the decrease in our bodies’ capabilities as we age. “The ability of your skin to produce vitamin D decreases the older you get, and vitamin-D deficiency has been shown to be common among those with Alzheimer’s.”[53]

A Few Concluding Remarks

Supplements – including the ones discussed here – are not supernatural. They cannot be expected to compensate for a lifetime of poor habits. So, firstly, I want to take a moment to reiterate the importance of what may be termed a “healthy lifestyle.”

Truly, diet and exercise are two indispensable keys to maintaining physical and mental fitness. In terms of nutritional guidelines, a good place to start is with the so-called Alzheimer’s “MIND Diet.” I have an entire article devoted to this topic, HERE.

Secondly, we are surrounded by environmental poisons and toxins and some of these severally – or possibly all (or some portion) of these jointly – may bear a measure of responsibility for dementias of one sort of other being as pervasive as they are. Therefore, part of your strategy needs to be minimizing your exposure, wherever possible. I have numerous posts on identifying and trying to eliminate these sorts of hazards.

These may include herbicides, metals, molds, pesticides, and myriad other things. For more information, see “Toxic Alzheimer’s? Household Hazards: Gases, Molds, Poisons” and “Home Contaminants and Hazards to Watch out For.”

For Further Reading[54]

Notes:

[1] For the details, see my dedicated article.

[2] Bruce Fife, The Coconut Oil Miracle, New York: Avery; Penguin, 2013, p. 188, <https://books.google.com/books?id=aLS1nQEACAAJ&pg=PA188>.

[3] Fife, The Coconut Oil Miracle, op. cit., p. 190.

[4] For completeness, I note that “the administration of glucose has [also] been shown to improve cognitive function, for example, memory performance in Alzheimer’s …[i]n clinical populations with severe cognitive deficits…”. Veronika Schöpf, Florian Fischmeister, Christian Windischberger, Florian Gerstl, Michael Wolzt, Karl Karlsson, and Ewald Moser, “Effects of Individual Glucose Levels on the Neuronal Correlates of Emotions,” Michael Smith and Andrew Scholey, eds., Nutritional Influences on Human Neurocognitive Functioning, p. 129; reproduction of article from Frontiers in Human Neuroscience, vol. 7, no. 212, May 21, 2013; cached at <https://books.google.com/books?id=0wKlBQAAQBAJ&pg=PA129>.

[5] Bruce Fife, Ketone Therapy: The Ketogenic Cleanse and Anti-Aging Diet, Colorado Springs, Colo.: Piccadilly Books, 2017, pp. 103-104, <https://books.google.com/books?id=5dEwDwAAQBAJ&pg=PA103>.

[6] I.e., be poisonous to the brain or nervous system.

[7] T. Hou, H. Yang, W. Wang, Q. Wu, Y. Tian, and J. Jia, “Sulforaphane Inhibits the Generation of Amyloid-β Oligomer and Promotes Spatial Learning and Memory in Alzheimer’s Disease (PS1V97L) Transgenic Mice,” Journal of Alzheimer’s Disease, vol. 62, no. 4, 2018, pp. 1803-1813, <https://www.ncbi.nlm.nih.gov/pubmed/29614663>.

[8] Nils-Erik Huseby, Elisabeth Sundkvist, and Gunbjørg Svineng, “Glutathione and Sulfur-Containing Amino Acids: Antioxidant and Conjugation Activities,” Roberta Masella, Giuseppe Mazza, eds., Glutathione and Sulfur Amino Acids in Human Health and Disease, Hoboken, N.J.: John Wiley & Sons, 2009, p. 112, <https://books.google.com/books?id=c9HznhSDlJAC&pg=PA112>.

[9] See, e.g., Ye Feng and Xiaochuan Wang, “Antioxidant Therapies for Alzheimer’s Disease,” Oxidative Medicine and Cellular Longevity, [vol. 2012,] Jul. 25, 2012, p. 472932, <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410354/>.

[10] Baolu Zhao, “Green Tea Polyphenols Protect Neurons Against Alzheimer’s Disease and Parkinson’s Disease,” Lester Packer, Helmut Sies, Manfred Eggersdorfer, and Enrique Cadenas, eds., Micronutrients and Brain Health, Boca Raton: CRC Press; Taylor & Francis, 2009, p. 256, <https://books.google.com/books?id=ylX-GBKyLLkC&pg=PA256>.

[11] “Why is neuroprotection important? Neuroprotection refers to mechanism and strategies used to protect against neuronal injury, degenerative, or death in the central nervous system (CNS), especially following acute disorders such as stroke or traumatic brain injury or as a result of chronic neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and multiple sclerosis (MS)…”.

[12] Emma Ramiro-Puig, Margarita Castell, Andrew McShea, George Perry, Mark Smith, and Gemma Casadesus, “Food Antioxidants and Alzheimer’s Disease,” Packer, Sies, Eggersdorfer, and Cadenas, Micronutrients and Brain Health, op. cit., p. 43.

[13] Zhao, op. cit., in Packer, Sies, Eggersdorfer, and Cadenas, Micronutrients and Brain Health, op. cit., p. 257.

[14] L. Xicota, J. Rodriguez-Morato, M. Dierssen, R. de la Torre, “Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer [sic] Disease,” Current Drug Targets, vol. 18, no. 2, 2017, pp. 174-195, <https://www.ncbi.nlm.nih.gov/pubmed/26302801>.

[15] Porter Shimer, New Hope for People with Alzheimer’s and Their Caregivers: Your Friendly, Authoritative Guide to the Latest in Traditional and Complementary Treatments, New York: Three Rivers Press; Crown Publ., 2002, p. 76, <https://books.google.com/books?id=wNli8hoE9TYC&pg=PA76>.

[16] Minyu Zhang, Liping Xu, and Hongjun Yang, “Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases,” International Journal of Molecular Sciences, vol. 19, no. 7, Jul. 6, 2018, p. 1970, <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073455/>.

[17] Solomon Habtemariam, The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer’s Disease,” Evidence-Based Complementary and Alternative Medicine, [vol. 2016,] Jan. 28, 2016, p. 2680409, <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749867/>.

[18] See Tadaaki Satou, Yuki Hanashima, Iho Mizutani, and Kazuo Koike, The Effect of Inhalation of Essential Oil from Rosmarinus Officinalis on Scopolamine‐induced Alzheimer’s Type Dementia Model Mice, Hoboken, N.J.: John Wiley & Sons, 2018.

[19] Nur Adalier and Heath Parker, “Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease,” Antioxidants (Switzerland), vol. 5, no. 4, Oct. 25, 2016, p. 40, <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187538/>.

[20] Adalier and Heath Parker, loc. cit.

[21] Ibid.

[22] Jenna Carroll, Estrogen and Progesterone-based Hormone Therapy and the Development of Alzheimer’s Disease, dissertation, Univ. of Southern California, 2009, <http://digitallibrary.usc.edu/cdm/ref/collection/p15799coll127/id/177259>.

[23] Though, at least one offbeat and possibly unreliable author appears to argue that “estrogen causes Alzheimer’s.” If interested in the counterpoint, see Raymond Peat’s self-published Progesterone in Orthomolecular Medicine, Eugene, Ore.: Raymond Peat, 1993, <https://books.google.com/books/about/Progesterone_in_Orthomolecular_Medicine.html?id=XdQ6AgAACAAJ>.

[24] B. Cholerton, C. Gleason, L. Baker, and S. Asthana, “Estrogen and Alzheimer’s Disease: The Story so Far,” Drugs & Aging, vol. 19, no. 6, 2002, pp. 405-427, <https://www.ncbi.nlm.nih.gov/pubmed/12149049>.

[25] Daniel Cardinali, Analía Furio, and María Ryes, “Melatonin and the Cytoprotective Role of Sleep,” Pedro Montilla and Isaac Túnez, ed., Melatonin: Present and Future, New York: Nova Biomedical Publ., 2007, p. 175, <https://books.google.com/books?id=cQn9NNUinwYC&pg=PA175>.

[26] See Russel Reiter, Dun-Xian Tan, and Faith Gultekin, “Melatonin Reduces Molecular Damage and Physiological Dysfunction in Experimental Models of Neurodegeneration,” Montilla and Túnez, ed., Melatonin, op. cit., p. 261.

[27] Though, whether melatonin decline is a cause of Alzheimer’s or an effect from it is an open question.

[28] Michael Foy, Michel Baudry, Roberta Brinton, and Richard Thompson, “Estrogen, Progesterone and Hippocampal Plasticity in Rodent Models,” G. Casadesus, ed., Handbook of Animal Models in Alzheimer’s Disease, Amsterdam: IOS Press, 2011, p. 109, <https://books.google.com/books?id=vddRI_qV5_gC&pg=PA109>.

[29] Ibid., p. 110.

[30] See, e.g., William Fryer and M. Shippen, The Testosterone Syndrome: The Critical Factor for Energy, Health, and Sexuality — Reversing the Male Menopause, New York: M. Evans & Co., 2001, p. 149, <https://books.google.com/books?id=UdXwbE7fGiEC&pg=PA149>.

[31] Martine Simard, Séverine Hervouet, and Hélène Forget,“Testosterone Depletion and Cognitive Impairment in Aging Men: A Possible Relationship Between Testosterone and Alzheimer’s Disease?” H. Sentowski, ed., Cognitive Disorders Research Trends, New York: Nova Science Publ., 2007, p. 51, <https://books.google.com/books?id=0R3I_ZMZVW4C&pg=PA51>.

[32] Edward Friedman and William Cane, The New Testosterone Treatment: How You and Your Doctor Can Fight Breast Cancer, Prostate Cancer, and Alzheimer’s, Amherst, N.Y.: Prometheus Books, 2013, p. 19, <https://books.google.com/books?id=ybRvDwAAQBAJ&pg=PA19>.

[33] James Greenblatt, Integrative Medicine for Alzheimer’s: The Breakthrough Natural Treatment Plan That Prevents Alzheimer’s Using Nutritional Lithium, Fort St. Victoria, British Columbia (Canada): Friesen Press, 2018, p. 27, <https://books.google.com/books?id=GNx8DwAAQBAJ&pg=PA27>.

[34] Michael Bauer and Michael Gitlin, The Essential Guide to Lithium Treatment, Basel, Switzerland: Springer, 2016, p. 93, <https://books.google.com/books?id=ePg0DAAAQBAJ&pg=PA93>.

[35] Be wary of the aspartate form. According to Greenblatt (op. cit., p. 73) it may be linked to “excitotoxicity,” which is “[o]ne common pathway of numerous degenerative diseases…,” according to Julie Holland, The Pot Book: A Complete Guide to Cannabis, New York: Simon & Schuster, 2010, eBook, <https://books.google.com/books?id=tV0oDwAAQBAJ>.

[36] Greenblatt, Integrative Medicine for Alzheimer’s, op. cit., pp. 73-74. Note that, in the past (say late 1940s to early 1950s), some heart patients taking lithium chloride “developed lithium poisoning”, ibid., p. 38.

[37] Holland, The Pot Book, loc. cit.

[38] Joan Bello, The Benefits of Marijuana: Physical, Psychological and Spiritual, Susquehanna, Penn.: Lifeservices Press, 2008, p. 159, <https://books.google.com/books?id=J0cdQ_yn9aEC&pg=PA159>. The same writer further relates this interesting historical anecdote. “In 2737 BC[,] …Emperor Shen Nung compiled the first Chinese Pharmacopoeia. Marijuana was classified as one of the Superior Elixirs of Immortality. It was prescribed for absent-mindedness.” Ibid.

[39] David Balfour and Marcus Munafò, The Neurobiology and Genetics of Nicotine and Tobacco, Cham, Switzerland: Springer, 2015, p. 96, <https://books.google.com/books?id=00KMBgAAQBAJ&pg=PA96>.

[40] Melissa Piasecki and Paul Newhouse, eds., Nicotine in Psychiatry: Psychopathology and Emerging Therapeutics, Washington, D.C. & London: American Psychiatric Press, 2000, p. 207, <https://books.google.com/books?id=YXKzlaQ4zLgC&pg=PA207>. See, also, Paul Newhouse, A. Potter, and R. Lenox, et al., “Effects of Nicotinic Agents on Human Cognition: Possible Therapeutic Applications in Alzheimer’s and Parkinson’s Diseases,” Medical Chemistry Research, vol. 2, 1993, pp. 628-642.

[41] Balfour and Munafò, The Neurobiology and Genetics of Nicotine and Tobacco, loc. cit. This nicotine research appears to be in early stages. As nearly as I can tell, the nicotine affects “different attentional functions” by acting through “nicotinic acetylcholine receptor[s]” which seems clearly to tie this intervention in with other research on Alzheimer’s relation to acetylcholine deficiency, cholinesterase inhibition, and so on. For more, see HERE & HERE.

[42] Shogo Tokuyama and Kazuo Nakamoto, “Pain as Modified by Polyunsaturated Fatty Acids,” Ronald Watson and Fabien De Meester, eds., Omega-3 Fatty Acids in Brain and Neurological Health, Amsterdam: Academic Press; Elsevier, 2014, p. 131, <https://books.google.com/books?id=HFgXAwAAQBAJ&pg=PA131>.

[43] Grace Giles, Caroline Mahoney, and Robin Kanarek, “Omega-3 Fatty Acids and Cognitive Behavior,” Watson and De Meester, eds., Omega-3 Fatty Acids in Brain and Neurological Health, p. 322.

[44] Alyssa Velasco and Zaldys Tan, “Fatty Acids and the Aging Brain,” Watson and De Meester, eds., Omega-3 Fatty Acids in Brain and Neurological Health, op. cit., p. 212.

[45] Ibid.

[46] Evening Primrose Oil is a good source for the related Omega-6 fatty acids. But watch these! Too much of them can be problematic.

[47] <https://books.google.com/books?id=4f8Nj83E3R8C&pg=PA238>.

[48] <https://books.google.com/books?id=4f8Nj83E3R8C&pg=PA258>.

[49] To make matters more confusing, there’s also the related Nicotinamide, a.k.a. Niacinamide.

[50] Vernon Mark, Reversing Memory Loss: Medically Proven Methods for Regaining, Strengthening, and Preserving Your Memory, Boston: Houghton Mifflin, 1993, p. 100, <https://books.google.com/books?id=CbxMI-MCNm0C>.

[51] Jonathan Graff-Radford, “Vitamin B-12: Can it improve memory in Alzheimer’s?” Mayo Clinic, Oct. 14, 2016, <https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/expert-answers/alzheimers/faq-20057895>. For more, see Abram Hoffer and Harold D. Foster, Feel Better, Live Longer with Vitamin B-3: Nutrient Deficiency and Dependency, Toronto: Canadian College of Naturopathic Medicine Press, 2007.

[52] Jonathan Graff-Radford, “Vitamin D: Can it prevent Alzheimer’s & dementia?” Mayo Clinic, May 30, 2018, <https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/expert-answers/vitamin-d-alzheimers/faq-20111272>.

[53] Joseph Mercola, Dark Deception: Discover the Truths About the Benefits of Sunlight Exposure, Nashville, Tenn.: Thomas Nelson, 2008, pp. 71-72, <https://books.google.com/books?id=ay99sWUvTxoC&pg=PA71>.

[54] From a scholarly perspective, see Arrigo Cicero, Federica Fogacci, and Maciej Banach, “Botanicals and Phytochemicals Active on Cognitive Decline: The Clinical Evidence,” Pharmacological Research, Dec. 28, 2017, pp. 204-212, <https://www.ncbi.nlm.nih.gov/pubmed/29289576>.